2021 International Congress of Diabetes and Metabolism

S4 Islet biology -AIBIS/AASD 1 : Beta cell dysfunction and diabetes LIVE Channel D	16:30~18:30 / Thursday 7 October Chairman:Ki-Ho Song, Jyuhn-Huarng Juang	Overview
Beta cell dysfunction is one of the most important pathological phenomena in the development of diabetes. This session will cover the various genetic and molecular factors that affect beta cell function and discuss the link between beta cell dysfunction and diabetes. This session will hopefully help to enhance our understanding of the pathophysiology of diabetes as well as the role of beta cells as therapeutic targets in diabetes.
Naoya Murao Kobe University, Japan	S4-1Persistent enhancement of glucose metabolism dysregulates β cell function and identity in aging and diabetes
Kenneth King-yip CHENG The Hong Kong Polytechnic University, China	S4-2The downstream metabolites of branched chain amino acids trigger pancreatic beta cell dysfunction in type 2 diabetes
Chung-Ze Wu Taipei Medical University, Taiwan(ROC)	S4-3Deficiency of urokinase plasminogen activator link to impair beta cell regeneration and insulin secretion in type 2 diabetes mellitus
Peter Leiluo Geng The University of Hong Kong, China	S4-4Two rare cases: intractable hypoglycemia caused by antibody against exogenous insulin and insulin receptor autoantibody

S12 Islet biology -AIBIS/AASD 2 : Incretin: from gut to brain LIVE Channel D	13:20~15:20 / Friday 8 October Chairman:Kun-Ho Yoon, Nobuya Inagaki	Overview
Since incretin was discovered in 1986, breakthroughs have been made in the treatment of diabetes. Incretin is not only closely related to blood glucose control, but also has a pleiotropic effect, affecting various organs. It is also known to play an important role in the brain-gut axis. This session will take an in-depth look at several recent studies on incretin, from the regulation of incretin secretion to its role in other organs, and how to identify insulin-secreting cells.
Chi-Ming Wong The Hong Kong Polytechnic University, China	S12-1Metabolomics analysis reveals the protection mechanism of GLP-1 analogue Dulaglutide on high-fat diet-induced chronic kidney disease in mice
Juhyun Song Chonnam National University, Korea	S12-2Role of exendin-4 in brain insulin resistance, mitochondrial function, and neurite outgrowth in neurons under obesity condition
Tomonobu Hatoko Kyoto University, Japan	S12-3A novel analysis of intestinal morphology and incretin-producing cells using tissue optical clearing and 3D-imaging
Udayakumar Karunakaran Yeungnam University, Korea	S12-4Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system

S20 Islet biology -AIBIS/AASD 3 : Beta cell mass and bioengineered islets LIVE Channel D	14:30~16:30 / Saturday 9 October Chairman:Yu-Bae Ahn, Karen Lam	Overview
There has been evidence that type 2 diabetes is mainly caused by a lack of β-cell mass, including autopsy studies with diverse populations. Regardless of the development of diabetes, beta cell mass can be affected even before birth. In this session, the first two talks will introduce recent findings on how beta cell mass is regulated during perinatal and lactation. Recent research on islet transplantation is largely divided into two types: how to utilize various cell sources and how to efficiently transplant islets. The latter two talks in this session will present the results of recent research on bioengineered islets for successful islet transplantation.
Chia-Rui Shen Chang Gung University, Taiwan	S20-1Development of multi-functional MR contrast agents facilitating the graft tracking and immunomodulation in islet transplantation
Hyeongseok Kim Chungnam National University, Korea	S20-2Lactation improves pancreatic β cell mass and function through serotonin production
Akira Endo Tohoku University, Japan	S20-3Phagocytosis by macrophages plays a main role in pancreatic β cell mass reduction during the perinatal period
Ying-Chieh Chen National Tsing-Hua University, Taiwan	S20-4Bioengineering vascularized islet for subcutaneous transplantation
Nathaniel S. Hwang Seoul National University, Korea	S20-5Novel enzymatic cross-linking-based hydrogel nanofilm caging system on pancreatic β cell spheroid for long-term blood glucose regulation

Main symposia